Caspase 3 anticorps (AA 29-175)

N° du produit ABIN7112361

Cet anticorps anti-Caspase 3 est un anticorps Souris Monoclonal détectant Caspase 3 dans WB, IHC, ELISA et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Caspase 3 anticorps (AA 29-175) (ABIN7112361)

Antigène: Caspase 3 (CASP3)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 2G7

Détail du produit anti-Caspase 3 anticorps

Épitope: AA 29-175

Fonction: CASP3 antibody

Purification: protein A+G purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 29-175aa

Immunogen: caspase 3, apoptosis-related cysteine peptidase

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:300, IF: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Caspase 3

Antigène: Caspase 3 (CASP3)

Autre désignation: CASP3

Sujet:

Synonyms: Caspase-3 (CASP-3)|Apopain|Cysteine protease CPP32 (CPP-32)|Protein Yama|SREBP cleavage activity 1 (SCA-1)|Caspase-3 subunit p17|Caspase-3 subunit p12|CASP3|CPP32

Background: Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.

Poids moléculaire: 32-35 kDa, 19 kDa, 17 kDa

ID gène: 836

UniProt: P42574

Pathways: Apoptose, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation